Exploring the Link Between Sweetener Consumption and Endometrial Cancer Risk
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Exploring the Link Between Sweetener Consumption and Endometrial Cancer Risk


Endometrial cancer (EC), one of the most common cancers affecting women, has seen a significant rise in incidence over recent decades. Identifying modifiable risk factors is crucial for prevention strategies. A study examines the potential impact of sweetener consumption, both nutritional (e.g., sugar) and non-nutritional (e.g., artificial sweeteners), on the risk of developing EC.


The meta-analysis included twelve studies, totaling ten cohort studies and two case-control studies. The findings revealed a higher incidence of EC among participants who consumed sweeteners, with a combined OR of 1.15. Notably, consumption of nutritional sweeteners was consistently associated with an increased risk of EC (OR = 1.25). In contrast, non-nutritional sweeteners did not show a significant association with EC risk, indicating no increased risk from these substances.

Subgroup Analysis

Detailed analysis further differentiated the effects of different types of sweeteners:

  • Nutritional Sweeteners: Strong association with increased EC risk, likely due to mechanisms related to obesity, insulin resistance, and hormonal imbalance.
  • Non-Nutritional Sweeteners: No clear link to EC risk, suggesting they might be a safer alternative in terms of EC risk, although the evidence remains inconclusive.


The results underscore the importance of dietary choices in relation to endometrial cancer risk. The distinction between nutritional and non-nutritional sweeteners is crucial, as they appear to have different impacts on EC risk. Nutritional sweeteners, which are energy-providing, were associated with a higher risk, potentially through pathways related to obesity and metabolic dysfunction.


Given the growing evidence, reducing the intake of nutritional sweeteners could be a prudent measure to mitigate the risk of EC. However, while non-nutritional sweeteners did not increase EC risk, further research is necessary to fully understand their long-term health impacts.


This meta-analysis highlights significant associations between sweetener type and endometrial cancer risk, emphasizing the need for public health strategies to address dietary sugar intake as a modifiable risk factor for EC. 

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3.Subgroup Analysis